Speed, temperature, wind, hills. Drive through 80 degree weather on relatively level freeways and maintain 55-60 MPH (often the flow of traffic in L.A.), and your range will likely be close to EPA figures. However, if you head out to Arizona in winter on a cold night (high 20's or low 30's), dealing with some of the steep hillsides that exist, common desert head-winds and keep up with the common flow of traffic on wide open desert freeways at 80 MPH and you'll likely end up with about 55-60% of the rated range. Slap a trailer on it and you'll be fortunate to make it 100 miles on a full charge. Without the trailer, probably in the 170 to 190 mile range. Likewise, if you end up on a basically level side road in good weather (over 70 degrees) with no wind at a steady pace of around 40 MPH, likely would get in the 400 mile range, without AC on.
Also, per manufacturers, wheel size impacts range. Naturally, if the truck is loaded to capacity, that will impact range too. Tonneau cover open will likely create drag and impact range. Lower ride height on highways will improve range. Using the Heater sucks up A LOT of battery. AC, not quite as bad. Tire pressure. If you go off-roading a lower your pressure down into the 20's or 30's, will adversely impact your highway range versus the recommended pressure at around 48 psi.
The list goes on and on. So many things can impact range. Those are the most common ones. When travelling, I always plan my trips based on about 60% as I'm not one that wants to drive conservatively (hyper-mile). I want to drive like I would in any other vehicle. So, my rule of thumb for long highway trips is around 60% of rated range and I'm usually pretty close.